Publications

Selected Publications

* : Equal First Author
¶: Corresponding Author

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Full publications list

Peer-reviewed International Journal publications (SCI/SCIE)

2022



1. “Identification of shared loci associated with both Crohn’s disease and leprosy in east Asians.” Hum Mol Genet. 31(22):3934-3944.
   Jung S, Park D, Lee HS, Kim Y, Baek J, Hwang SW, Park SH, Yang SK, Ye BD, Buhm Han, Sun Y, Liu H, Zhang F, Liu J, Song K.
   
   
2. “FastRNA: an efficient solution for PCA of single-cell RNA sequencing data based on a batch-accounting count model.” Am J Hum Genet. 109(11):1974-1985.
   Lee H, Buhm Han.
   
   
3. “Exploration of shared features of B cell receptor and T cell receptor repertoires reveals distinct clonotype clusters.” Front Immunol. 13:1006136.
   Hong SB, Shin YW, Hong JB, Lee SK, Buhm Han.
   
   
4. “Phenome-wide association study of the major histocompatibility complex region in the Korean population identifies novel association signals.” Hum Mol Genet. 31(15):2655-2667.
   Kim C*, Kim YJ*, Choi W, Jang HM, Hwang MY, Jung S, Lim H, Hong SB, Yoon K, Kim BJ, Park HY, Buhm Han.
   
   
5. “MarcoPolo: a method to discover differentially expressed genes in single-cell RNA-seq data without depending on prior clustering.” Nucleic Acids Res. 50(12):e71.
   Kim C*, Lee H*, Jeong J, Jung K, Buhm Han.
   
   
6. “A theory-based practical solution to correct for sex-differential participation bias.” Genome Biol. 23(1):138.
   Lee H, Buhm Han.
   
   
7. “Dynamic increase of M2 macrophages is associated with disease progression of colorectal cancers following cetuximab-based treatment.” Sci Rep. 31;12(1):1678.
   Kim HD, Kim SY, Kim J, Kim JE, Hong YS, Buhm Han, Tak E, Ryu YM, Kim SY, Kim TW.
   
   
8. “Expression of neurofibromin 1 in colorectal cancer and cetuximab resistance.” Oncol Rep. 47(1):15.
   Tak E, Kim M, Cho Y, Choi S, Kim J, Buhm Han, Kim HD, Jang CS, Kim JE, Hong YS, Kim SY, Kim TW.
   
   



2021



9. “Identification of Three Novel Susceptibility Loci for Inflammatory Bowel Disease in Koreans in an Extended Genome-Wide Association Study.” J Crohns Colitis. 2021 Nov 8;15(11):1898-1907.br> Jung S, Ye BD, Lee HS, Baek J, Kim G, Park D, Park SH, Yang SK, Buhm Han, Liu J, Song K.
   
   
10. “A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.” Nat Genet. 2021 Oct;53(10):1504-1516.
    Luo Y, Kanai M, Choi W, Li X, Sakaue S, Yamamoto K, Ogawa K, Gutierrez-Arcelus M, Gregersen PK, Stuart PE, Elder JT, Forer L, Schönherr S, Fuchsberger C, Smith AV, Fellay J, Carrington M, Haas DW, Guo X, Palmer ND, Chen YI, Rotter JI, Taylor KD, Rich SS, Correa A, Wilson JG, Kathiresan S, Cho MH, Metspalu A, Esko T, Okada Y, Buhm Han; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, McLaren PJ, Raychaudhuri S.
    
    
11. “A systematic analysis of protein-altering exonic variants in chronic obstructive pulmonary disease.” Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1;321(1):L130-L143.
    Moll M, Jackson VE, Yu B, Grove ML, London SJ, Gharib SA, Bartz TM, Sitlani CM, Dupuis J, O’Connor GT, Xu H, Cassano PA, Patchen BK, Kim WJ, Park J, Kim KH, Buhm Han, Barr RG, Manichaikul A, Nguyen JN, Rich SS, Lahousse L, Terzikhan N, Brusselle G, Sakornsakolpat P, Liu J, Benway CJ, Hall IP, Tobin MD, Wain LV, Silverman EK, Cho MH, Hobbs BD.
    
    
12. “Rare variants regulate expression of nearby individual genes in multiple tissues.” PLoS Genet. 2021 Jun 1;17(6):e1009596.
    Li J, Kong N, Buhm Han, Sul JH.
    
    
13. “A genome wide association study for lung function in the Korean population using an exome array.” Korean J Intern Med. 2021 Mar;36(Suppl 1):S142-S150.
    Lee KS, Kim KH, Oh YM, Buhm Han, Kim WJ.
    
    
14. “Accurate imputation of human leukocyte antigens with CookHLA.” Nature Communications. 12 (1): 1264.
    Seungho Cook, Wanson Choi, Hyunjoon Lim, Yang Luo, Kunhee Kim, Xiaoming Jia, Soumya Raychaudhuri, Buhm Han
    
    
15. “HATK: HLA analysis toolkit.” Bioinformatics .
    Wanson Choi, Yang Luo, Soumya Raychaudhuri, Buhm Han
    
    
16. “PLEIO: a method to map and interpret pleiotropic loci with GWAS summary statistics.” The American Journal of Human Genetics. 108 (1): 36-48.
    Cue Hyunkyu Lee, Huwenbo Shi, Bogdan Pasaniuc, Eleazar Eskin, Buhm Han
    
    



2020



17. “Genetic stratification of depression in UK Biobank.”,Translational Psychiatry 10 (1), 1-8 3.
    David M Howard, Lasse Folkersen, Jonathan RI Coleman, Mark J Adams, Kylie Glanville, Thomas Werge, Saskia P Hagenaars, Buhm Han, David Porteous, Archie Campbell, Toni-Kim Clarke, Gerome Breen, Patrick F Sullivan, Naomi R Wray, Cathryn M Lewis, Andrew M McIntosh
    
    
18. “Expression Quantitative Trait Loci (eQTL) Mapping in Korean Patients With Crohn’s Disease and Identification of Potential Causal Genes Through Integration With Disease Associations.” Frontiers in Genetics 11, 486 1.
    Seulgi Jung, Wenting Liu, Jiwon Baek, Jung Won Moon, Byong Duk Ye, Ho-Su Lee, Sang Hyoung Park, Suk-Kyun Yang, Buhm Han, Jianjun Liu, Kyuyoung Song
    
    
19. “Integrating scRNA-seq data of multiple donors increases cell-type identification accuracy.” bioRxiv
    Hanbin Lee, Chanwoo Kim, Juhee Jeong, Keehoon Jung, Buhm Han
    
    
20. “A High-Resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response.” medRxiv .
    Yang Luo, Masahiro Kanai, Wanson Choi, Xinyi Li, Kenichi Yamamoto, Kotaro Ogawa, Maria Gutierrez-Arcelus, Peter K Gregersen, Philip E Stuart, James T Elder, Jacques Fellay, Mary Carrington, David W Haas, Xiuqing Guo, Nicholette D Palmer, Yii-Der Ida Chen, Jerome I Rotter, Kent D Taylor, Steve Rich, Adolfo Correa, James G Wilson, Sekar Kathiresan, Michael Cho, Andres Metspalu, Tonu Esko, Yukinori Okada, Buhm Han , Paul J Mclaren, Soumya Raychaudhuri
    
    



2019



21. “Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk.” Human Molecular Genetics. 28 (20): 3498-3513.
    Jennie G Pouget, Buhm Han, Yang Wu, Emmanuel Mignot, Hanna M Ollila, Jonathan Barker, Sarah Spain, Nick Dand, Richard Trembath, Javier Martin, Maureen D Mayes, Lara Bossini-Castillo, Elena López-Isac, Ying Jin, Stephanie A Santorico, Richard A Spritz, Hakon Hakonarson, Constantin Polychronakos, Soumya Raychaudhuri, Jo Knight.
    
    
22. “Effects of smoking on the association of human leukocyte antigen with ulcerative colitis.” Journal of Gastroenterology and Hepatology. 34 (10): 1777-1783. (https://doi.org/10.1111/jgh.14695)
    Ho‐Su Lee, Kihyun Kim, Seulgi Jung, Myunghee Hong, Byoung Mok Kim, Dae‐sung Yoo, Jung Won Moon, Jiwon Baek, Sung Wook Hwang, Sang Hyoung Park, Suk‐Kyun Yang, Buhm Han, Kyuyoung Song, Byong Duk Ye.
    
    
23. “Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes.” Genome Biology. 20:175. Aug 2019.
    Kunhee Kim, Hyungryul Baik, Chloe Soohyun Jang, Jin Kyung Roh, Eleazer Eskin, and Buhm Han¶
    
    
24. “Prognostic value of the association between MHC class I downregulation and PD-L1 upregulation in head and neck squamous cell carcinoma patients.” Scientific Reports. 9:7680. May 2019
    Shin Hye Yoo, Bhumsuk Keam, Chan-Young Ock, Sehui Kim, Buhm Han, Ji-Won Kim, Keun-Wook Lee, Yoon Kyung Jeon, Kyeong Cheon Jung, Eun-Jae Chung, Seong Keun Kwon, Soon-Hyun Ahn, Myung-Whun Sung & Dae Seog Heo.
    
    



2018



25. “Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.” Nature Communications. 9:1825. Dec 2018.
    Alvaro N. Barbeira, Scott P. Dickinson, Rodrigo Bonazzola, Jiamao Zheng, Heather E. Wheeler, Jason M. Torres, Eric S. Torstenson, Kaanan P. Shah, Tzintzuni Garcia, Todd L. Edwards, Eli A. Stahl, Laura M. Huckins, GTEx Consortium, Dan L. Nicolae, Nancy J. Cox, and Hae Kyung Im.
    
    
26. “Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn’s disease in Asians.” Human Molecular Genetics. 27(22):3901-3910. Nov 2018
    Buhm Han*, Masato Akiyama*, Kyung-Kon Kim, Hyunjung Oh, Hyunchul Choi, Cue Hyunkyu Lee, Seulgi Jung, Ho-Su Lee, Emma E Kim, Seungho Cook, Talin Haritunians, Keiko Yamazaki, Sang Hyoung Park, Byong Duk Ye, Dermot PB McGovern, Motohiro Esaki, Takaaki Kawaguchi, Seik-Soon Khor, Kent D Taylor, Jerome I Rotter, Yasuo Suzuki, Toshiyuki Matsui, Satoshi Motoya, So-Young Bang, Tae-Hwan Kim, Yukihide Momozawa, Yoichiro Kamatani, Katsushi Tokunaga, Michiaki Kubo, Yukinori Okada, Suk-Kyun Yang, Kyuyoung Song
    
    
27. “An intergenic variant rs9268877 between HLA-DRA and HLA-DRB contributes to the clinical course and long-term outcome of ulcerative colitis.” Journal of Crohn’s and Colitis. 12(9):1113-1121. Aug 2018
    Ho-Su Lee, Suk-Kyun Yang, Myunghee Hong, Seulgi Jung, Byoung Mok Kim, Jung Won Moon, Sang Hyoung Park, Byong Duk Ye, Seak Hee Oh, Kyung Mo Kim, Yong Sik Yoon, Chang Sik Yu, Jiwon Baek, Cue Hyunkyu Lee, Buhm Han, Jianjun Liu, Talin Haritunians, Dermot PB McGovern, Kyuyoung Song
    
    
28. “An Association Mapping Framework To Account for Potential Sex Difference in Genetic Architectures.” Genetics. 209(3):685-698. July 2018
    Eun Yong Kang, Cue Hyunkyu Lee, Nicholas A. Furlotte, Jong Wha J. Joo, Emrah Kostem, Noah Zaitlen, Eleazar Eskin¶ and Buhm Han¶
    
    
29. “Immunochip meta-analysis of inflammatory bowel disease identifies three novel loci and four novel associations in previously reported loci.” Journal of Crohn’s and Colitis. 12(6):730-741.  May 2018
    Myunghee Hong, Byong Duk Ye, Suk-Kyun Yang, Seulgi Jung, Ho-Su Lee, Byoung Mok Kim, Soo Bin Lee, Jeonghoon Hong, Jiwon Baek, Sang Hyoung Park, Buhm Han, Yi Li, Wenting Liu, Talin Haritunians, Kent D Taylor, Jerome I Rotter, So-Young Bang, Tae-Hwan Kim, Dermot PB McGovern, Jianjun Liu, Kyuyoung Song
    
    
30. “Association of CDKN2A/CDKN2B with inflammatory bowel disease in Koreans.” Journal of Gastroenterology and Hepatology. 33(4):887-893. Apr 2018.
    Ho‐Su Lee, Soo Bin Lee, Byoung Mok Kim, Myunghee Hong, Seulgi Jung, Jeonghoon Hong, Jiwon Baek, Buhm Han, Seak Hee Oh, Kyung Mo Kim, Sang Hyoung Park, Suk‐Kyun Yang, Byong Duk Ye, Kyuyoung Song
    
    



2017



31. “Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis.” Genome Research. 27(11):1859–1871. 2017
    Fan Yang, Jiebiao Wang, The GTEx Consortium, Brandon L. Pierce, and Lin S. Chen
    
    
32. “Co-expression networks reveal the tissue-specific regulation of transcription and splicing” Genome Research. 27(11):1843–1858. 2017
    Ashis Saha, Yungil Kim, Ariel D.H. Gewirtz, Brian Jo, Chuan Gao, Ian C. McDowell, The GTEx Consortium, Barbara E. Engelhardt, and Alexis Battle
    
    
33. “FOLD: A method to optimize power in meta-analysis of genetic association studies with overlapping subjects.” Bioinformatics. 33(24):3947-3954. 2017
    Emma E Kim, Seunghoon Lee, Cue Hyunkyu Lee, Hyunjung Oh, Kyuyoung Song, Buhm Han¶
    
    
34. “Genetic effects on gene expression across human tissues.” Nature. 550:204-213. 2017
    The GTEx Consortium
    
    
35. “Increasing the power of meta-analysis of genome-wide association studies to detect heterogeneous effects.” Bioinformatics. 33(14):i379-i388. 2017
    Cue Hyunkyu Lee, Eleazar Eskin, Buhm Han¶
    
    
36. “Applying meta-analysis to genotype-tissue expression data from multiple tissues to identify eQTLs and increase the number of eGenes.” Bioinformatics. 33(14):i67-i74. 2017
    Dat Duong, Lisa Gai, Sagi Snir, Eun Yong Kang, Buhm Han, Jae Hoon Sul, Eleazar Eskin
    
    
37. “X chromosome-wide association study identifies a susceptibility locus for inflammatory bowel disease in Koreans.” Journal of Crohn’s and Colitis. 11(7):820-830. 2017
    Ho-Su Lee, Hyunjung Oh, Suk-Kyun Yang, Jiwon Baek, Seulgi Jung, Myunghee Hong, Kyung Mo Kim, Hyoung Doo Shin, Kyung-Jo Kim, Sang Hyoung Park, Byong Duk Ye, Buhm Han, Kyuyoung Song
    
    
38. “Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases.” Annals of the Rheumatic Diseases. 76(4):765-772. 2017
    Hinks A, Bowes J, Cobb J, Ainsworth HC, Marion MC, Comeau ME, Sudman M, Han B; Juvenile Arthritis Consortium for Immunochip, Becker ML, Bohnsack JF, de Bakker PI, Haas JP, Hazen M, Lovell DJ, Nigrovic PA, Nordal E, Punnaro M, Rosenberg AM, Rygg M, Smith SL, Wise CA, Videm V, Wedderburn LR, Yarwood A, Yeung RS, Prahalad S, Langefeld CD, Raychaudhuri S, Thompson SD, Thomson W
    
    



2016



39. “Identification of loci at 1q21 and 16q23 that affect susceptibility to inflammatory bowel disease in Koreans.” Gastroenterology. 151(6):1096-1099. e4. 2016
    Suk-Kyun Yang, Myunghee Hong, Hyunjung Oh, Hui-Qi Low, Seulgi Jung, Seonjoo Ahn, Youngjin Kim, Jiwon Baek, Cue Hyunkyu Lee, Eunji Kim, Kyung Mo Kim, Byong Duk Ye, Kyung-Jo Kim, Sang Hyoung Park, Ho-Su Lee, Inchul Lee, Hyoung Doo Shin, Buhm Han, Dermot PB McGovern, Jianjun Liu, Kyuyoung Song
    
    
40. “Discovering single nucleotide polymorphisms regulating human Gene expression using allele specific expression from RNA-seq data.” Genetics. 204(3):1057-1064. 2016
    Eun Yong Kang, Lisa J Martin, Serghei Mangul, Warin Isvilanonda, Jennifer Zou, Eyal Ben-David, Buhm Han, Aldons J Lusis, Sagiv Shifman, Eleazar Eskin
    
    
41. “Generation and molecular characterization of pancreatic cancer patient-derived xenografts reveals their heterologous nature.” Oncotarget. 7(38):62533-62546. 2016
    Jaeyun Jung, Cue Hyunkyu Lee, Hyang Sook Seol, Yeon Sook Choi, Eunji Kim, Eun Ji Lee, Je-Keun Rhee, Shree Ram Singh, Eun Sung Jun, Buhm Han, Seung Mo Hong, Song Cheol Kim, Suhwan Chang
    
    
42. “Shared genetic risk factors of intracranial, abdominal and thoracic aneurysms.” Journal of the American Heart Association. 5(7):e002603. 2016
    Femke N.G. van ’t Hof, Ynte M. Ruigrok, Cue Hyunkyu Lee, Stephan Ripke, Graig Anderson, Mariza de Andrade, Annette F. Baas, Jan D. Blankensteijn, Erwin P. Böttinger, Matthew J. Bown, Joseph Broderick, Philippe Bijlenga, David S. Carrell, Dana C. Crawford, David R. Crosslin, Christian Ebeling, Johan G Eriksson, Myriam Fornage, Tatiana Foroud, Mikael von und zu Fraunberg, Christoph M. Friedrich, Emília I. Gaál, Omri Gottesman, Dong-chuan Guo, Seamus C Harrison FRCS, Juha Hernesniemi, Albert Hofman, Ituro Inoue, Juha E. Jääskeläinen, Gregory T. Jones, Lambertus A.L.M. Kiemeney, Riku Kivisaari, Nerissa Ko, Seppo Koskinen, Michiaki Kubo, Iftikhar J. Kullo, Helena Kuivaniemi, Mitja I. Kurki, Aki Laakso, Dongbing Lai, Suzanne M. Leal, Hanna Lehto, Scott A. LeMaire, Siew-Kee Low, Jennifer Malinowski MS, Catherine A. McCarty, Dianna M. Milewicz, Thomas H. Mosley, Yusuke Nakamura, Hirofumi Nakaoka, Mika Niemelä, Jennifer Pacheco, BA, Peggy L. Peissig, Joanna Pera, Laura Rasmussen-Torvik, Marylyn D. Ritchie, Fernando Rivadeneira, Andre M. van Rij, Regie Lyn P. Santos-Cortez, Athanasios Saratzis, Agnieszka Slowik, Atsushi Takahashi, Gerard Tromp, André G. Uitterlinden, Shefali S. Verma, Sita H. Vermeulen, Gao T. Wang, Aneurysm Consortium, Vascular Research Consortium of New Zealand, Buhm Han, Gabriël J.E. Rinkel FRCP(E), Paul I.W. de Bakker
    
    
43. “ForestPMPlot: a flexible tool for visualizing heterogeneity between studies in meta-analysis.” G3: Genes Genomes Genetics. 6(7):1793-8. 2016
    Eun Yong Kang, Yurang Park, Xiao Li, Ayellet V. Segre, Buhm Han¶, and Eleazar Eskin¶
    
    
44. “Imputing phenotypes for genome-wide association studies.” The American Journal of Human Genetics. 99(1):89-103. 2016
    Farhad Hormozdiari, Eun Yong Kang, Michael Bilow, Eyal Ben-David, Chris Vulpe, Stela McLachlan, Aldons J. Lusis, Buhm Han¶, Eleazar Eskin¶
    
    
45. “A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.” Nature Genetics. 48(7):803-10. 2016
    Buhm Han¶*, Jennie G Pouget*, Kamil Slowikowski, Eli Stahl, Cue Hyunkyu Lee, Dorothee Diogo, Xinli Hu, Yu Rang Park, Eunji Kim, Peter K Gregersen, Solbritt Rantapää Dahlqvist, Jane Worthington, Javier Martin, Steve Eyre, Lars Klareskog, Tom Huizinga, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S Rich, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Naomi R Wray, Soumya Raychaudhuri¶
    
    
46. “A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping.” Human Molecular Genetics. 25(9):1857-66. 2016
    Buhm Han¶, Dat Duong, Jae Hoon Sul, Paul I. W. de Bakker, Eleazar Eskin, and Soumya Raychaudhuri
    
    
47. “Using genomic annotations increases statistical power to detect eGenes.” Bioinformatics. (Presented at ISMB2016) 32(12):i156-i163. 2016
    Dat Duong, Jennifer Zou, Farhad Hormozdiari, Jae Hoon Sul, Jason Ernst, Buhm Han¶, Eleazar Eskin¶
    
    
48. “Investigating the causal relationship of C-reactive protein with 32 complex somatic and psychiatric outcomes: A large scale cross-consortium Mendelian randomization study.” PLOS Medicine. 13(6): e1001976. 2016
    Bram P. Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E. Stuart, Javier Guterriez Achury, Vanisha Vanisha Mistry, Jonathan P Bradfield, Ana M Valdes, Jose Bras, Aleksey Shatunov, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D. Mayes, Evangelos Evangelou, Rajan P Nair, Struan F.A. G Grant, Constantin Polychronakos, Timothy R.D. Radstake, David A. van Heel, Melanie L Dunstan, Nicholas W. Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S. Markus, James T. Elder, Jo Knight, Dan E. Arking, Timothy D. Spector, Bobby P.C. Koeleman, Cornelia P. van Duijn, Javier Martin, Andrew P. Morris, Rinse K. Weersma, Cisca Wijmenga, Patricia Munroe, John R.B. Perry, Jennie G. Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z. Alizadeh, PAGE Consortium, International Stroke Genetics Consortium, Systematic Sclerosis Consortium, Treat OA Consortium Consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS Consortium, International Parkinson’s Disease Genomics Consortium, Autism Working Group of the Psychiatric Genomics Consortium, CKDGen Consortium, the GERAD1 Consortium, ICBP Consortium, Inflammation Working Group of the CHARGE Consortium
    
    
49. “Multiple testing correction in linear mixed models.” Genome Biology. 17(1):62, 2016
    Jong Wha J. Joo, Farhad Hormozdiari, Buhm Han¶, and Eleazar Eskin¶
    
    
50. “Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.” Nature Genetics. 48:510-518, 2016
    David Ellinghaus, Luke Jostins, Sarah L Spain, Adrian Cortes, Jörn Bethune, Buhm Han, Yu Rang Park, Soumya Raychaudhuri, Matthias Hübenthal, Trine Folseraas, Yunpeng Wang, Tonu Esko, Andres Metspalu, Harm-Jan Westra, Lude Franke, Tune Pers, Rinse Weersma, Collij Valerie, Mauro D’Amato, Jonas Halfvarson, Wolfgang Lieb, Franziska Degenhardt, Andreas J Forstner, Andrea Hofmann, The International IBD Genetics Consortium (IIBDGC), International Genetics of Ankylosing Spondylitis Consortium (IGAS), International PSC Study Group (IPSCSG), Collaborative Association Study of Psoriasis (CASP), Genetic Analysis of Psoriasis Consortium, Psoriasis Association Genetics Extension, Wellcome Trust Case Control Consortium, Stefan Schreiber, Ulrich Mrowietz, Brian D Juran, Konstantinos N Lazaridis, Anders M Dale, Richard C Trembath, Stephan Weidinger, Michael Weichenthal, Eva Ellinghaus, James T Elder, Jonathan NWN Barker, Ole A Andreassen, Dermot P McGovern, Tom H Karlsen, Jeffrey C Barrett, Miles Parkes, Matthew A Brown, Andre Franke
    
    
51. “Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.” Lancet Neurology. 15(2):174-184, 2016
    NINDS Stroke Genetics Network (SiGN), International Stroke Genetics Consortium (ISGC)
    
    



2015



52. “HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.” Proceedings of the National Academy of Sciences, 112(52):15970–15975, 2015
    Michael J Ombrello, Elaine F Remmers, Ioanna Tachmazidou, Alexei Grom, Dirk Foell, Johannes-Peter Haas, Alberto Martini, Marco Gattorno, Seza O ̈zen, Sampath Prahalad, Andrew S Zeft, John F Bohn- sack, Elizabeth D Mellins, Norman T Ilowite, Ricardo Russo, Claudio Len, Maria Odete E Hilario, Sheila Oliveira, Rae S M Yeung, Alan Rosenberg, Lucy R Wedderburn, Jordi Anton, Tobias Schwarz, Anne Hinks, Yelda Bilginer, Jane Park, Joanna Cobb, Colleen L Satorius, Buhm Han, Elizabeth Baskin, Sara Signa, Richard H Duerr, J P Achkar, M Ilyas Kamboh, Kenneth M Kaufman, Leah C Kottyan, Dalila Pinto, Stephen W Scherer, Marta E Alarc ́on-Riquelme, Elisa Docampo, Xavier Estivill, Ahmet Gul, British Society of Pediatric, Adolescent Rheumatology (BSPAR) Study Group, Childhood Arthritis Prospective Study (CAPS) Group, Randomized Placebo Phase Study of Rilonacept in sJIA (RAP- PORT) Investigators, Sparks-Childhood Arthritis Response to Medication Study (CHARMS) Group, Biologically Based Outcome Predictors in JIA (BBOP) Group, Paul I W de Bakker, Soumya Ray- chaudhuri, Carl D Langefeld, Susan Thompson, Eleftheria Zeggini, Wendy Thomson, Daniel L Kastner, Patricia Woo, the International Childhood Arthritis Genetics (INCHARGE) Consortium
    
    
53. “Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases.” Nature Genetics. 47(9):1085-1090. 2015
    Tobias L Lenz, Aaron J Deutsch, Buhm Han, Xinli Hu, Yukinori Okada, Stephen Eyre, Michael Knapp, Alexandra Zhernakova, Tom WJ Huizinga, Gonçalo Abecasis, Jessica Becker, Guy E Boeckxstaens, Wei-Min Chen, Andre Franke, Dafna D Gladman, Ines Gockel, Javier Gutierrez-Achury, Javier Martin, Rajan P Nair, Markus M Nöthen, Suna Onengut-Gumuscu, Proton Rahman, Solbritt Rantapää-Dahlqvist, Philip E Stuart, Lam C Tsoi, David A van Heel, Jane Worthington, Mira M Wouters, Lars Klareskog, James T Elder, Peter K Gregersen, Johannes Schumacher, Stephen S Rich, Cisca Wijmenga, Shamil R Sunyaev, Paul IW de Bakker, Soumya Raychaudhuri
    
    
54. “Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.” Nature Genetics. 47(8):898-905. 2015
    Xinli Hu, Aaron J Deutsch, Tobias L Lenz, Suna Onengut-Gumuscu, Buhm Han, Wei-Min Chen, Joanna MM Howson, John A Todd, Paul IW de Bakker, Stephen S Rich, Soumya Raychaudhuri
    
    
55. “Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci.” The American Journal of Human Genetics. 97(1):139-152. 2015
    Gosia Trynka, Harm-Jan Westra, Kamil Slowikowski, Xinli Hu, Han Xu, Barbara E Stranger, Buhm Han, Soumya Raychaudhuri
    
    
56. “Accurate and Fast Multiple-Testing Correction in eQTL Studies.” The American Journal of Human Genetics. 96(6):857-868. 2015
    Jae Hoon Sul, Towfique Raj, Simone de Jong, Paul IW de Bakker, Soumya Raychaudhuri, Roel A Ophoff, Barbara E Stranger, Eleazar Eskin¶, Buhm Han¶
    
    
57. “Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.” JAMA. 313(16):1645-1656. 2015
    Sebastien Viatte, Darren Plant, Buhm Han, Bo Fu, Annie Yarwood, Wendy Thomson, Deborah PM Symmons, Jane Worthington, Adam Young, Kimme L Hyrich, Ann W Morgan, Anthony G Wilson, John D Isaacs, Soumya Raychaudhuri, Anne Barton
    
    
58. “A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk.” Annals of The Rheumatic Diseases. 74(1):170-176, 2015 January
    Annie Yarwood, Buhm Han, Soumya Raychaudhuri, John Bowes, Mark Lunt, Dimitrios A Pappas, Joel Kremer, Jeffrey D Greenberg, Robert Plenge, Rheumatoid Arthritis Consortium International (RACI), Jane Worthington, Anne Barton, Steve Eyre
    
    



2014



59. “The HLA-DRβ1 Amino Acid Positions 11-13-26 Explain the Majority of SLE-MHC Associations.” Nature Communications. 5:5902, 2014 December
    Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, Yukinori Okada, Buhm Han, Woei-Yuh Saw, Yik-Ying Teo, Sang-Cheol Bae
    
    
60. “Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations.” Human Molecular Genetics. 23(25):6916-26, 2014 December
    Yukinori Okada, Kwangwoo Kim, Buhm Han, Nisha E Pillai, Rick T-H Ong, Woei-Yuh Saw, Ma Luo, Lei Jiang, Jian Yin, So-Young Bang, Hye-Soon Lee, Matthew A Brown, Sang-Cheol Bae, Huji Xu, Yik-Ying Teo, Paul IW De Bakker, Soumya Raychaudhuri
    
    
61. “Variation at HLA-DRB1 is associated with resistance to enteric fever.” Nature Genetics. 46(12):1333-6, 2014 December
    Sarah J. Dunstan, Nguyen Thi Hue, Buhm Han, Zheng Li, Trinh Thi Bich Tram, Kar Seng Sim, Christopher M. Parry, Nguyen Tran Chinh, Ha Vinh, Nga Tran Vu Thieu, Phat Voong Vinh, Samir Koirala, Sabina Dongol, Amit Arjyal, Abhilasha Karkey, Olita Shilpakar, Christiane Dolecek, Jia Nee Foo, Le Thi Phuong, Mai Ngoc Lanh, Tan Do, Tin Aung, Do Nu Hon, Yik Ying Teo, Martin L Hibberd, Katherine L.  Anders, Yukinori Okada, Soumya Raychaudhuri, Cameron P. Simmons, Stephen Baker, Paul I.W. de Bakker, Buddha Basnyat, Tran Tinh Hien, Jeremy J. Farrar, Chiea Chuen Khor
    
    
62. “Fine-mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.” The American Journal of Human Genetics. 95(2):162-172. 2014 August
    Yukinori Okada*, Buhm Han*, Lam C. Tsoi, Philip E. Stuart, Eva Ellinghaus, Trilokraj Tejasvi, Vinod Chandran, Fawnda Pellett, Remy Pollock, Anne M. Bowcock, Gerald G. Krueger, Michael Weichenthal, John J. Voorhees, Proton Rahman, Peter K. Gregersen, Andre Franke, Rajan P. Nair, Goncalo R. Abecasis, Dafna D. Gladman, James T. Elder, Paul I.W. de Bakker, and Soumya Raychaudhuri
    
    
63. “Effectively identifying regulatory hotspots while capturing expression heterogeneity in gene expression studies.” Genome Biology. 15(4):R61. 2014
    Jong Wha J Joo, Jae Hoon Sul, Buhm Han, Chun Ye, Eleazar Eskin
    
    
64. “Fine-mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.” The American Journal of Human Genetics. 94(4):522-523. 2014
    Buhm Han, Dorothee Diogo, Steve Eyre, Henrik Kallberg, Alexandra Zhernakova, John Bowes, Leonid Padyukov, Yukinori Okada, Miguel A. Gonzalez-Gay, Solbritt Rantapaa-Dahlqvist, Javier Martin, Tom W J Huzinga, Robert Plenge, Jane Worthington, Peter K. Gregersen, Lars Klareskog, Paul I. W. de Bakker, Soumya Raychaudhuri
    
    
65. “Fast Pairwise IBD Association Testing in Genome-wide Association Studies.” Bioinformatics. 30(2):206-13. 2014
    Buhm Han*, Eun Yong Kang*, Soumya Raychaudhuri, Paul I. W. de Bakker, Eleazar Eskin
    
    
66. ““Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice.” PLOS Genetics. 10(1): e1004022. 2014
    Eun Yong Kang*, Buhm Han*, Nicholas Furlotte*, Jong Wha Joo, Diana Shih, Richard Davis, Aldons J. Lusis, Eleazar Eskin
    
    



2013



67. “Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells.” Proceedings of the National Academy of Sciences. 110(47):19030-5. 2013
    Xinli Hu, Hyun Kim, Patrick J. Brennan, Buhm Han, Clare Baecher-Allan, Philip De Jager, Michael B. Brenner, Soumya Raychaudhuri
    
    
68. “Genome-wide association study of Tourette’s Syndrome.” Molecular Psychiatry. 18(6):721-8. 2013 June
    Jeremiah M. Scharf, Dongmei Yu, Carol A. Mathews, Benjamin M. Neale, S. Evelyn Stewart, Jesen A Fagerness, Patrick Evans, Eric Gamazon, Christopher K. Edlund, Susan Service, Anna Tikhomirov, Lisa Osiecki, Cornelia Illmann, Anna Pluzhnikov, Anuar Konkashbaev, Lea K Davis, Buhm Han, Jacquelyn Crane, Priya Moorjani, Andrew T. Crenshaw, Melissa A. Parkin, Victor I. Reus, Thomas L. Lowe, Martha Rangel-Lugo, Sylvain Chouinard, Yves Dion, Simon Girard, Danielle C Cath, Jan H Smit, Robert A. King, Thomas Fernandez, James F. Leckman, Kenneth K. Kidd, Judith R. Kidd, Andrew J. Pakstis, Matthew State, Luis Diego Herrera, Roxana Romero, Eduardo Fournier, Paul Sandor, Cathy L Barr, Nam Phan, Varda Gross-Tsur, Fortu Benarroch, Yehuda Pollak, Cathy L. Budman, Ruth D. Bruun, Gerald Erenberg, Allan L Naarden, Paul C Lee, Nicholas Weiss, Barbara Kremeyer, Gabriel Bedoya Berro, Desmond Campbell, Julio C. Cardona Silgado, William Cornejo Ochoa, Sandra C. Mesa Restrepo, Heike Muller, Ana V. Valencia Duarte, Gholson J Lyon, Mark Leppert, Jubel Morgan, Robert Weiss, Marco A. Grados, Kelley Anderson, Sarah Davarya, Harvey Singer, John WalkupJoseph Jankovic, Jay A. Tischfield, Gary A. Heiman, Donald L. Gilbert, Pieter J. Hoekstra, Mary M. Robertson, Roger Kurlan, Chunyu Liu, J. Raphael Gibbs and Andrew Singleton for the North American Brain Expression Consortium, John Hardy for the UK Human Brain Expression Database, Eric Strengman, Roel Ophoff, Michael Wagner, Rainald Moessner, Daniel B. Mirel, Danielle Posthuma, Chiara SabattiEleazar Eskin, David V. Conti, James A. Knowles, Andres Ruiz-Linares, Guy A. Rouleau, Shaun Purcell, Peter Heutink, Ben A. Oostra, William McMahon, Nelson Freimer, Nancy J. Cox, David L. Pauls
    
    
69. “IPED: Inheritance Path Based Pedigree Reconstruction Algorithm Using Genotype Data.” Journal of Computational Biology. 20(10):780-91. 2013
    Dan He, Zhanyong Wang, Buhm Han, Laxmi Parida, Eleazar Eskin
    
    
70. “Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches.” PLOS Genetics. 9(6): e1003491. 2013
    Jae Hoon Sul*, Buhm Han*, Chun Ye*, Ted Choi, Eleazar Eskin
    
    
71. “Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens.” PLOS One. 8(6):e64683. 2013
    Xiaoming Jia*, Buhm Han*, Suna Onengut-Gumuscu, Wei-Min Chen, Patrick J. Concannon, Stephen S. Rich, Soumya Raychaudhuri, Paul I.W. de Bakker
    
    
72. “Rare Variant Association Testing under Low- Coverage Sequencing.” Genetics. 194(3):769-79. 2013
    Oron Navon, Jae Hoon Sul, Buhm Han, Lucia Conde, Paige Bracci, Jacques Riby, Christine Skibola, Eleazar Eskin, Eran Halperin
    
    
73. “Hap-seq: An Optimal Algorithm for Haplotype Phasing with Imputation using Sequencing Data.” Journal of Computational Biology. 20(2):80-92. 2013
    Dan He, Buhm Han, Eleazar Eskin
    
    
74. “Chromatin marks identify critical cell types for fine mapping complex trait variants.” Nature Genetics. 45(2):124-30. 2013
    Gosia Trynka, Cynthia Sandor, Buhm Han, Han Xu, Barbara E Stranger, X Shirley Liu, Soumya Raychaudhuri
    
    



~2012



75. “Incorporating prior information into association studies” Bioinformatics. 28 (12):i147-i153, 2012. Also appeared in Proceedings of the Twentieth Annual Conference on Intelligent Systems for Molecular Biology (ISMB-2012)
    Gregory Darnell, Dat Duong, Buhm Han, Eleazar Eskin
    
    
76. “Interpreting Meta-Analyses of Genome-Wide Association Studies.” PLOS Genetics. 8(3):e1002555, 2012
    Buhm Han, Eleazar Eskin
    
    
77. “Increasing Power of Groupwise Association Test with Likelihood Ratio Test.” Journal of Computational Biology. 18(11):1611-1624, 2011
    Jae Hoon Sul, Buhm Han, Eleazar Eskin
    
    
78. “Random Effects Model Aimed At Discovering Associations in Meta-Analysis of Genome-Wide Association Studies.” The American Journal of Human Genetics. 88(5):586-598, 2011
    Buhm Han, Eleazar Eskin
    
    
79. “An Optimal Weighted Aggregated Association Test for Identification of Rare Variants Involved in Common Diseases.” Genetics. 188(1):181-8, 2011
    Jae Hoon Sul, Buhm Han, Dan He, Eleazar Eskin
    
    
80. “Postassociation Cleaning Using Linkage Disequilibrium Information.” Genetic Epidemiology. 35(1):1-10, 2011
    Buhm Han, Brian Hackel, Eleazar Eskin
    
    
81. “Fine Mapping in 94 Inbred Mouse Strains Using a High-Density Haplotype Resource.” Genetics. 185(3):1081-1095, 2010
    Andrew Kirby, Hyun Min Kang, Claire M. Wade, Chris Cotsapas, Emrah Kostem, Buhm Han, Nick Furlotte, Eun Yong Kang, Manuel Rivas, Molly A. Bogue, Kelly A. Frazer, Frank M. Johnson, Erica J. Beilharz, David R. Cox, Eleazar Eskin, Mark J. Daly
    
    
82. “Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers.” PLOS Genetics. 5(4):e1000456, 2009
    Buhm Han, Hyun Min Kang, Eleazar Eskin
    
    
83. ““Structural Alignment of Pseudo-knotted RNA.” Journal of Computational Biology. 15(5):489-504, 2008
    Buhm Han*, Banu Dost*, Vineet Bafna, Shaojie Zhang
    
    
84. ““Efficient Association Study Design via Power-Optimized Tag SNP Selection.” Annals of Human Genetics. 72(6):834-47, 2008
    Buhm Han, Hyun Min Kang, Myeong Seong Seo, Noah Zaitlen, Eleazar Eskin
    
    

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Refereed Domestic Journal Papers

1. “Analysis of differences in human leukocyte antigen between the two Wellcome Trust Case Control Consortium control datasets.” Genomics & informatics. 17(3): e29 2019

Chloe Soohyun Jang, Wanson Choi, Seungho Cook, and Buhm Han

2. “MergeReference: A Tool for Merging Reference Panels for HLA Imputation.” Genomics & informatics. 15(3):108-111. 2017

Seungho Cook, Buhm Han

3. “Comparison of Two Meta-Analysis Methods: Inverse-Variance-Weighted Average and Weighted Sum of Z-Scores.” Genomics & informatics. 14(4):173-180. 2016

Cue Hyunkyu Lee, Seungho Cook, Ji Sung Lee, Buhm Han

4.“Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans.” Genomics & Informatics. 13(4):126-131. 2015

Soo Heon Kwak, Yoon Ji Kim, Jeesoo Chae, Cue Hyunkyu Lee, Buhm Han, Jong-Il Kim, Hye Seung Jung, Young Min Cho, and Kyong Soo Park

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Refereed Conference Proceedings

1. “IPED: Inheritance Path Based Pedigree Reconstruction Algorithm Using Genotype Data.” In Proceedings of the Seventeenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2013). Beijing, China: April 7-10, 2013

Dan He, Zhanyong Wang, Buhm Han, Laxmi Parida, Eleazar Eskin

2. “Hap-seq: An Optimal Algorithm for Haplotype Phasing with Imputation using Sequencing Data.” In Proceedings of the Sixteenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2012). Barcelona, Spain: April 21-24, 2012

Dan He, Buhm Han, Eleazar Eskin

3. “Increasing Power of Groupwise Association Test with Likelihood Ratio Test.” In Proceedings of the Fifteenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2011). Vancouver, Canada: March 28-31, 2011

Jae Hoon Sul, Buhm Han, Eleazar Eskin

4. “An Adaptive and Memory Efficient Algorithm for Genotype Imputation.” In Proceedings of the Thirteenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2009). Tucson, AZ: May 18-21, 2009

Hyun Min Kang, Noah Zaitlen, Buhm Han, Eleazar Eskin

5. “Efficient Genome Wide Tagging by Reduction to SAT.” In Proceedings of the 8th Workshop on Algorithms in Bioinformatics (WABI-2008). University Karlsruhe, Germany: September 15-17, 2008

Arthur Choi, Noah Zaitlen, Buhm Han, Knot Pipatsrisawat, Adnan Darwiche, Eleazar Eskin

6. “Structural Alignment of Pseudo-knotted RNA.” In Proceedings of the Tenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2006). Venice, Italy, April 2-5, 2006

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Invited Review Papers

1. “Multiple Testing in Genetic Epidemiology.” Encyclopedia of Life Sciences. DOI:10.1002/9780470015902.a0022497, 2010

Buhm Han, Eleazar Eskin

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Refereed Workshop Papers

1. “Leveraging Joint Test Status Distribution for an Optimal Signficance Testing.” In Proceedings of the NIPS 2009 Workshop on Machine Learning in Computational Biology. Whistler, CA: December 11th, 2009

Buhm Han, Chun Ye, Ted Choi, Eleazar Eskin