PLEIO (Pleiotropic Locus Exploration and Interpretation using Optimal test) : a summary-statistic-based framework to map and interpret pleiotropic loci in a joint analysis of multiple diseases and complex traits. Our method maximizes power by systematically accounting for genetic correlations and heritabilities of the traits in the association test. Any set of related phenotypes, binary or quantitative traits with different…
CookHLA : an accurate and efficient HLA imputation method. Human leukocyte antigen (HLA) genes in the major histocompatibility complex (MHC) region influence many immune-related disease phenotypes. Discovering which HLA alleles or amino acids drive phenotypes often requires fine-mapping analysis in tens of thousands of samples, of which HLA typing can be prohibitively costly. Fortunately, the recent development of imputation methods enabled…
Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes Genomic global positioning system (GPS) applies the multilateration technique commonly used in the GPS to genomic data. In the framework we present here, investigators calculate genetic distances from their samples to reference samples, which are from data held in the public domain,…
FOLD: A method to optimize power in meta-analysis of genetic association studies with overlapping subjects. Journal : Bioinformatics. 33(24):3947-3954. 2017 Authors : Emma E Kim, Seunghoon Lee, Cue Hyunkyu Lee, Hyunjung Oh, Kyuyoung Song, Buhm Han¶ See more
RE2C: Increasing the power of meta-analysis of genome-wide association studies to detect heterogeneous effects. Journals : Bioinformatics. 33(14):i379-i388. 2017 Authors : Cue Hyunkyu Lee, Eleazar Eskin, Buhm Han¶
BUHMBOX: A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases Journal : Nature Genetics. 48(7):803-10. 2016 Authors : Buhm Han¶*, Jennie G Pouget*, Kamil Slowikowski, Eli Stahl, Cue Hyunkyu Lee, Dorothee Diogo, Xinli Hu, Yu Rang Park, Eunji Kim, Peter K Gregersen, Solbritt Rantapää Dahlqvist, Jane Worthington, Javier Martin, Steve Eyre,…
