+82-2-3668-7619 hanlab.snu@gmail.com103, Daehak-ro, Jongno-gu, Seoul, Republic of Korea

Publications

Selected Publications

* : Equal First Author
: Corresponding Author
  • Title : “Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes” Genome Biology. (2019) 20:175. 2019
  • Authors : Kunhee Kim*, Hyungryul Baik*, Chloe Soohyun Jang, Jin Kyung Roh, Eleazer Eskin, Buhm Han¶
  • See more

  • Title : “FOLD: A method to optimize power in meta-analysis of genetic association studies with overlapping subjects.” Bioinformatics. 33(24):3947-3954. 2017
  • Authors : Emma E Kim, Seunghoon Lee, Cue Hyunkyu Lee, Hyunjung Oh, Kyuyoung Song, Buhm Han¶
  • See more

  • Title : “Increasing the power of meta-analysis of genome-wide association studies to detect heterogeneous effects.” Bioinformatics. 33(14):i379-i388. 2017
  • Authors : Cue Hyunkyu Lee, Eleazar Eskin, Buhm Han¶
  • See more

  • Title : “Imputing phenotypes for genome-wide association studies.” The American Journal of Human Genetics. 99(1):89-103. 2016
  • Authors : Farhad Hormozdiari, Eun Yong Kang, Michael Bilow, Eyal Ben-David, Chris Vulpe, Stela McLachlan, Aldons J. Lusis, Buhm Han¶, Eleazar Eskin¶
  • See more

  • Title : “A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.” Nature Genetics. 48(7):803-10. 2016
  • Authors : Buhm Han¶*, Jennie G Pouget*, Kamil Slowikowski, Eli Stahl, Cue Hyunkyu Lee, Dorothee Diogo, Xinli Hu, Yu Rang Park, Eunji Kim, Peter K Gregersen, Solbritt Rantapää Dahlqvist, Jane Worthington, Javier Martin, Steve Eyre, Lars Klareskog, Tom Huizinga, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S Rich, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Naomi R Wray, Soumya Raychaudhuri¶
  • See more

  • Title : “A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping.” Human Molecular Genetics. 25(9):1857-66. 2016
  • Authors : Buhm Han¶, Dat Duong, Jae Hoon Sul, Paul I. W. de Bakker, Eleazar Eskin, and Soumya Raychaudhuri
  • See more

  • Title : “Using genomic annotations increases statistical power to detect eGenes.” Bioinformatics. (Presented at ISMB2016) 32(12):i156-i163. 2016
  • Authors : Dat Duong, Jennifer Zou, Farhad Hormozdiari, Jae Hoon Sul, Jason Ernst, Buhm Han¶, Eleazar Eskin¶
  • See more

  • Title : “Multiple testing correction in linear mixed models.” Genome Biology. 17(1):62, 2016
  • Authors : Jong Wha J. Joo, Farhad Hormozdiari, Buhm Han¶, and Eleazar Eskin¶
  • See more

  • Title : “Accurate and Fast Multiple-Testing Correction in eQTL Studies.” The American Journal of Human Genetics. 96(6):857-868. 2015
  • Authors : Jae Hoon Sul, Towfique Raj, Simone de Jong, Paul IW de Bakker, Soumya Raychaudhuri, Roel A Ophoff, Barbara E Stranger, Eleazar Eskin¶, Buhm Han¶
  • See more

  • Title : “Fine-mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.” The American Journal of Human Genetics. 95(2):162-172. 2014 August
  • Authors : Yukinori Okada*, Buhm Han*, Lam C. Tsoi, Philip E. Stuart, Eva Ellinghaus, Trilokraj Tejasvi, Vinod Chandran, Fawnda Pellett, Remy Pollock, Anne M. Bowcock, Gerald G. Krueger, Michael Weichenthal, John J. Voorhees, Proton Rahman, Peter K. Gregersen, Andre Franke, Rajan P. Nair, Goncalo R. Abecasis, Dafna D. Gladman, James T. Elder, Paul I.W. de Bakker, and Soumya Raychaudhuri
  • See more

  • Title : “Fine-mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.” The American Journal of Human Genetics. 94(4):522-523. 2014 (Selected as F1000 recommendation)
  • Authors : Buhm Han, Dorothee Diogo, Steve Eyre, Henrik Kallberg, Alexandra Zhernakova, John Bowes, Leonid Padyukov, Yukinori Okada, Miguel A. Gonzalez-Gay, Solbritt Rantapaa-Dahlqvist, Javier Martin, Tom W J Huzinga, Robert Plenge, Jane Worthington, Peter K. Gregersen, Lars Klareskog, Paul I. W. de Bakker, Soumya Raychaudhuri
  • See more

  • Title : “Fast Pairwise IBD Association Testing in Genome-wide Association Studies.”Bioinformatics. 30(2):206-13. 2014
  • Authors : Buhm Han*, Eun Yong Kang*, Soumya Raychaudhuri, Paul I. W. de Bakker, Eleazar Eskin
  • See more

  • Title : “Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice.” PLOS Genetics. 10(1): e1004022. 2014
  • Authors : Eun Yong Kang*, Buhm Han*, Nicholas Furlotte*, Jong Wha Joo, Diana Shih, Richard Davis, Aldons J. Lusis, Eleazar Eskin
  • See more

  • Title : “Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches.” PLOS Genetics. 9(6): e1003491. 2013
  • Authors : Jae Hoon Sul*, Buhm Han*, Chun Ye*, Ted Choi, Eleazar Eskin
  • See more

  • Title : “Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens.” PLOS One. 8(6):e64683. 2013
  • Authors : Xiaoming Jia*, Buhm Han*, Suna Onengut-Gumuscu, Wei-Min Chen, Patrick J. Concannon, Stephen S. Rich, Soumya Raychaudhuri, Paul I.W. de Bakker
  • See more

  • Title : “Interpreting Meta-Analyses of Genome-Wide Association Studies.” PLOS Genetics. 8(3):e1002555, 2012
  • Authors : Buhm Han, Eleazar Eskin
  • See more

  • Title : “Random Effects Model Aimed At Discovering Associations in Meta-Analysis of Genome-Wide Association Studies.” The American Journal of Human Genetics. 88(5):586-598, 2011
  • Authors : Buhm Han, Eleazar Eskin
  • See more

  • Title : “Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers.” PLOS Genetics. 5(4):e1000456, 2009
  • Authors : Buhm Han, Hyun Min Kang, Eleazar Eskin
  • See more


Full publications list

Peer-reviewed International Journal publications (SCI/SCIE)

2018
  1. “Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn’s disease in Asians.” Human Molecular Genetics. 27(22):3901-3910. Nov 2018

Buhm Han*, Masato Akiyama*, Kyung-Kon Kim, Hyunjung Oh, Hyunchul Choi, Cue Hyunkyu Lee, Seulgi Jung, Ho-Su Lee, Emma E Kim, Seungho Cook, Talin Haritunians, Keiko Yamazaki, Sang Hyoung Park, Byong Duk Ye, Dermot PB McGovern, Motohiro Esaki, Takaaki Kawaguchi, Seik-Soon Khor, Kent D Taylor, Jerome I Rotter, Yasuo Suzuki, Toshiyuki Matsui, Satoshi Motoya, So-Young Bang, Tae-Hwan Kim, Yukihide Momozawa, Yoichiro Kamatani, Katsushi Tokunaga, Michiaki Kubo, Yukinori Okada, Suk-Kyun Yang, Kyuyoung Song

2. “An intergenic variant rs9268877 between HLA-DRA and HLA-DRB contributes to the clinical course and long-term outcome of ulcerative colitis.” Journal of Crohn’s and Colitis. 12(9):1113-1121. Aug 2018

Ho-Su Lee, Suk-Kyun Yang, Myunghee Hong, Seulgi Jung, Byoung Mok Kim, Jung Won Moon, Sang Hyoung Park, Byong Duk Ye, Seak Hee Oh, Kyung Mo Kim, Yong Sik Yoon, Chang Sik Yu, Jiwon Baek, Cue Hyunkyu Lee, Buhm Han, Jianjun Liu, Talin Haritunians, Dermot PB McGovern, Kyuyoung Song

3. “An Association Mapping Framework To Account for Potential Sex Difference in Genetic Architectures.” Genetics. 209(3):685-698. July 2018

Eun Yong Kang, Cue Hyunkyu Lee, Nicholas A. Furlotte, Jong Wha J. Joo, Emrah Kostem, Noah Zaitlen, Eleazar Eskin¶ and Buhm Han

4. “Immunochip meta-analysis of inflammatory bowel disease identifies three novel loci and four novel associations in previously reported loci.” Journal of Crohn’s and Colitis. 12(6):730-741.  May 2018

Myunghee Hong, Byong Duk Ye, Suk-Kyun Yang, Seulgi Jung, Ho-Su Lee, Byoung Mok Kim, Soo Bin Lee, Jeonghoon Hong, Jiwon Baek, Sang Hyoung Park, Buhm Han, Yi Li, Wenting Liu, Talin Haritunians, Kent D Taylor, Jerome I Rotter, So-Young Bang, Tae-Hwan Kim, Dermot PB McGovern, Jianjun Liu, Kyuyoung Song

5. “Association of CDKN2A/CDKN2B with inflammatory bowel disease in Koreans.” Journal of Gastroenterology and Hepatology. 33(4):887-893. Apr 2018.

Ho‐Su Lee, Soo Bin Lee, Byoung Mok Kim, Myunghee Hong, Seulgi Jung, Jeonghoon Hong, Jiwon Baek, Buhm Han, Seak Hee Oh, Kyung Mo Kim, Sang Hyoung Park, Suk‐Kyun Yang, Byong Duk Ye, Kyuyoung Song

2017

6. “Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis.” Genome Research. 27(11):1859–1871. 2017

Fan Yang, Jiebiao Wang, The GTEx Consortium, Brandon L. Pierce, and Lin S. Chen

7. “Co-expression networks reveal the tissue-specific regulation of transcription and splicing” Genome Research. 27(11):1843–1858. 2017

Ashis Saha, Yungil Kim, Ariel D.H. Gewirtz, Brian Jo, Chuan Gao, Ian C. McDowell, The GTEx Consortium, Barbara E. Engelhardt, and Alexis Battle

8. “FOLD: A method to optimize power in meta-analysis of genetic association studies with overlapping subjects.” Bioinformatics. 33(24):3947-3954. 2017

Emma E Kim, Seunghoon Lee, Cue Hyunkyu Lee, Hyunjung Oh, Kyuyoung Song, Buhm Han¶

9. “Genetic effects on gene expression across human tissues.” Nature. 550:204-213. 2017

The GTEx Consortium

10. “Increasing the power of meta-analysis of genome-wide association studies to detect heterogeneous effects.” Bioinformatics. 33(14):i379-i388. 2017

Cue Hyunkyu Lee, Eleazar Eskin, Buhm Han¶

11. “Applying meta-analysis to genotype-tissue expression data from multiple tissues to identify eQTLs and increase the number of eGenes.” Bioinformatics. 33(14):i67-i74. 2017

Dat Duong, Lisa Gai, Sagi Snir, Eun Yong Kang, Buhm Han, Jae Hoon Sul, Eleazar Eskin

12. “X chromosome-wide association study identifies a susceptibility locus for inflammatory bowel disease in Koreans.” Journal of Crohn’s and Colitis. 11(7):820-830. 2017

Ho-Su Lee, Hyunjung Oh, Suk-Kyun Yang, Jiwon Baek, Seulgi Jung, Myunghee Hong, Kyung Mo Kim, Hyoung Doo Shin, Kyung-Jo Kim, Sang Hyoung Park, Byong Duk Ye, Buhm Han, Kyuyoung Song

13. “Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases.” Annals of the Rheumatic Diseases. 76(4):765-772. 2017

Hinks A, Bowes J, Cobb J, Ainsworth HC, Marion MC, Comeau ME, Sudman M, Han B; Juvenile Arthritis Consortium for Immunochip, Becker ML, Bohnsack JF, de Bakker PI, Haas JP, Hazen M, Lovell DJ, Nigrovic PA, Nordal E, Punnaro M, Rosenberg AM, Rygg M, Smith SL, Wise CA, Videm V, Wedderburn LR, Yarwood A, Yeung RS, Prahalad S, Langefeld CD, Raychaudhuri S, Thompson SD, Thomson W

2016

14. “Identification of loci at 1q21 and 16q23 that affect susceptibility to inflammatory bowel disease in Koreans.” Gastroenterology. 151(6):1096-1099. e4. 2016

Suk-Kyun Yang, Myunghee Hong, Hyunjung Oh, Hui-Qi Low, Seulgi Jung, Seonjoo Ahn, Youngjin Kim, Jiwon Baek, Cue Hyunkyu Lee, Eunji Kim, Kyung Mo Kim, Byong Duk Ye, Kyung-Jo Kim, Sang Hyoung Park, Ho-Su Lee, Inchul Lee, Hyoung Doo Shin, Buhm Han, Dermot PB McGovern, Jianjun Liu, Kyuyoung Song

15. “Discovering single nucleotide polymorphisms regulating human Gene expression using allele specific expression from RNA-seq data.” Genetics. 204(3):1057-1064. 2016

Eun Yong Kang, Lisa J Martin, Serghei Mangul, Warin Isvilanonda, Jennifer Zou, Eyal Ben-David, Buhm Han, Aldons J Lusis, Sagiv Shifman, Eleazar Eskin

16. “Generation and molecular characterization of pancreatic cancer patient-derived xenografts reveals their heterologous nature.” Oncotarget. 7(38):62533-62546. 2016

Jaeyun Jung, Cue Hyunkyu Lee, Hyang Sook Seol, Yeon Sook Choi, Eunji Kim, Eun Ji Lee, Je-Keun Rhee, Shree Ram Singh, Eun Sung Jun, Buhm Han, Seung Mo Hong, Song Cheol Kim, Suhwan Chang

17. “Shared genetic risk factors of intracranial, abdominal and thoracic aneurysms.” Journal of the American Heart Association. 5(7):e002603. 2016

Femke N.G. van ’t Hof, Ynte M. Ruigrok, Cue Hyunkyu Lee, Stephan Ripke, Graig Anderson, Mariza de Andrade, Annette F. Baas, Jan D. Blankensteijn, Erwin P. Böttinger, Matthew J. Bown, Joseph Broderick, Philippe Bijlenga, David S. Carrell, Dana C. Crawford, David R. Crosslin, Christian Ebeling, Johan G Eriksson, Myriam Fornage, Tatiana Foroud, Mikael von und zu Fraunberg, Christoph M. Friedrich, Emília I. Gaál, Omri Gottesman, Dong-chuan Guo, Seamus C Harrison FRCS, Juha Hernesniemi, Albert Hofman, Ituro Inoue, Juha E. Jääskeläinen, Gregory T. Jones, Lambertus A.L.M. Kiemeney, Riku Kivisaari, Nerissa Ko, Seppo Koskinen, Michiaki Kubo, Iftikhar J. Kullo, Helena Kuivaniemi, Mitja I. Kurki, Aki Laakso, Dongbing Lai, Suzanne M. Leal, Hanna Lehto, Scott A. LeMaire, Siew-Kee Low, Jennifer Malinowski MS, Catherine A. McCarty, Dianna M. Milewicz, Thomas H. Mosley, Yusuke Nakamura, Hirofumi Nakaoka, Mika Niemelä, Jennifer Pacheco, BA, Peggy L. Peissig, Joanna Pera, Laura Rasmussen-Torvik, Marylyn D. Ritchie, Fernando Rivadeneira, Andre M. van Rij, Regie Lyn P. Santos-Cortez, Athanasios Saratzis, Agnieszka Slowik, Atsushi Takahashi, Gerard Tromp, André G. Uitterlinden, Shefali S. Verma, Sita H. Vermeulen, Gao T. Wang, Aneurysm Consortium, Vascular Research Consortium of New Zealand, Buhm Han, Gabriël J.E. Rinkel FRCP(E), Paul I.W. de Bakker

18. “ForestPMPlot: a flexible tool for visualizing heterogeneity between studies in meta-analysis.” G3: Genes Genomes Genetics. 6(7):1793-8. 2016

Eun Yong Kang, Yurang Park, Xiao Li, Ayellet V. Segre, Buhm Han¶, and Eleazar Eskin¶

19. “Imputing phenotypes for genome-wide association studies.” The American Journal of Human Genetics. 99(1):89-103. 2016

Farhad Hormozdiari, Eun Yong Kang, Michael Bilow, Eyal Ben-David, Chris Vulpe, Stela McLachlan, Aldons J. Lusis, Buhm Han¶, Eleazar Eskin¶

20. “A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.” Nature Genetics. 48(7):803-10. 2016

Buhm Han¶*, Jennie G Pouget*, Kamil Slowikowski, Eli Stahl, Cue Hyunkyu Lee, Dorothee Diogo, Xinli Hu, Yu Rang Park, Eunji Kim, Peter K Gregersen, Solbritt Rantapää Dahlqvist, Jane Worthington, Javier Martin, Steve Eyre, Lars Klareskog, Tom Huizinga, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S Rich, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Naomi R Wray, Soumya Raychaudhuri¶

21. “A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping.” Human Molecular Genetics. 25(9):1857-66. 2016

Buhm Han¶, Dat Duong, Jae Hoon Sul, Paul I. W. de Bakker, Eleazar Eskin, and Soumya Raychaudhuri

22. “Using genomic annotations increases statistical power to detect eGenes.” Bioinformatics. (Presented at ISMB2016) 32(12):i156-i163. 2016

Dat Duong, Jennifer Zou, Farhad Hormozdiari, Jae Hoon Sul, Jason Ernst, Buhm Han¶, Eleazar Eskin¶

23. “Investigating the causal relationship of C-reactive protein with 32 complex somatic and psychiatric outcomes: A large scale cross-consortium Mendelian randomization study.” PLOS Medicine. 13(6): e1001976. 2016

Bram P. Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E. Stuart, Javier Guterriez Achury, Vanisha Vanisha Mistry, Jonathan P Bradfield, Ana M Valdes, Jose Bras, Aleksey Shatunov, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D. Mayes, Evangelos Evangelou, Rajan P Nair, Struan F.A. G Grant, Constantin Polychronakos, Timothy R.D. Radstake, David A. van Heel, Melanie L Dunstan, Nicholas W. Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S. Markus, James T. Elder, Jo Knight, Dan E. Arking, Timothy D. Spector, Bobby P.C. Koeleman, Cornelia P. van Duijn, Javier Martin, Andrew P. Morris, Rinse K. Weersma, Cisca Wijmenga, Patricia Munroe, John R.B. Perry, Jennie G. Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z. Alizadeh, PAGE Consortium, International Stroke Genetics Consortium, Systematic Sclerosis Consortium, Treat OA Consortium Consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS Consortium, International Parkinson’s Disease Genomics Consortium, Autism Working Group of the Psychiatric Genomics Consortium, CKDGen Consortium, the GERAD1 Consortium, ICBP Consortium, Inflammation Working Group of the CHARGE Consortium

24. “Multiple testing correction in linear mixed models.” Genome Biology. 17(1):62, 2016

Jong Wha J. Joo, Farhad Hormozdiari, Buhm Han¶, and Eleazar Eskin¶

25. “Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.” Nature Genetics. 48:510-518, 2016

David Ellinghaus, Luke Jostins, Sarah L Spain, Adrian Cortes, Jörn Bethune, Buhm Han, Yu Rang Park, Soumya Raychaudhuri, Matthias Hübenthal, Trine Folseraas, Yunpeng Wang, Tonu Esko, Andres Metspalu, Harm-Jan Westra, Lude Franke, Tune Pers, Rinse Weersma, Collij Valerie, Mauro D’Amato, Jonas Halfvarson, Wolfgang Lieb, Franziska Degenhardt, Andreas J Forstner, Andrea Hofmann, The International IBD Genetics Consortium (IIBDGC), International Genetics of Ankylosing Spondylitis Consortium (IGAS), International PSC Study Group (IPSCSG), Collaborative Association Study of Psoriasis (CASP), Genetic Analysis of Psoriasis Consortium, Psoriasis Association Genetics Extension, Wellcome Trust Case Control Consortium, Stefan Schreiber, Ulrich Mrowietz, Brian D Juran, Konstantinos N Lazaridis, Anders M Dale, Richard C Trembath, Stephan Weidinger, Michael Weichenthal, Eva Ellinghaus, James T Elder, Jonathan NWN Barker, Ole A Andreassen, Dermot P McGovern, Tom H Karlsen, Jeffrey C Barrett, Miles Parkes, Matthew A Brown, Andre Franke

26. “Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.” Lancet Neurology. 15(2):174-184, 2016

NINDS Stroke Genetics Network (SiGN), International Stroke Genetics Consortium (ISGC)

2015

27. “HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.” Proceedings of the National Academy of Sciences, 112(52):15970–15975, 2015

Michael J Ombrello, Elaine F Remmers, Ioanna Tachmazidou, Alexei Grom, Dirk Foell, Johannes-Peter Haas, Alberto Martini, Marco Gattorno, Seza O ̈zen, Sampath Prahalad, Andrew S Zeft, John F Bohn- sack, Elizabeth D Mellins, Norman T Ilowite, Ricardo Russo, Claudio Len, Maria Odete E Hilario, Sheila Oliveira, Rae S M Yeung, Alan Rosenberg, Lucy R Wedderburn, Jordi Anton, Tobias Schwarz, Anne Hinks, Yelda Bilginer, Jane Park, Joanna Cobb, Colleen L Satorius, Buhm Han, Elizabeth Baskin, Sara Signa, Richard H Duerr, J P Achkar, M Ilyas Kamboh, Kenneth M Kaufman, Leah C Kottyan, Dalila Pinto, Stephen W Scherer, Marta E Alarc ́on-Riquelme, Elisa Docampo, Xavier Estivill, Ahmet Gul, British Society of Pediatric, Adolescent Rheumatology (BSPAR) Study Group, Childhood Arthritis Prospective Study (CAPS) Group, Randomized Placebo Phase Study of Rilonacept in sJIA (RAP- PORT) Investigators, Sparks-Childhood Arthritis Response to Medication Study (CHARMS) Group, Biologically Based Outcome Predictors in JIA (BBOP) Group, Paul I W de Bakker, Soumya Ray- chaudhuri, Carl D Langefeld, Susan Thompson, Eleftheria Zeggini, Wendy Thomson, Daniel L Kastner, Patricia Woo, the International Childhood Arthritis Genetics (INCHARGE) Consortium

28. “Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases.” Nature Genetics. 47(9):1085-1090. 2015

Tobias L Lenz, Aaron J Deutsch, Buhm Han, Xinli Hu, Yukinori Okada, Stephen Eyre, Michael Knapp, Alexandra Zhernakova, Tom WJ Huizinga, Gonçalo Abecasis, Jessica Becker, Guy E Boeckxstaens, Wei-Min Chen, Andre Franke, Dafna D Gladman, Ines Gockel, Javier Gutierrez-Achury, Javier Martin, Rajan P Nair, Markus M Nöthen, Suna Onengut-Gumuscu, Proton Rahman, Solbritt Rantapää-Dahlqvist, Philip E Stuart, Lam C Tsoi, David A van Heel, Jane Worthington, Mira M Wouters, Lars Klareskog, James T Elder, Peter K Gregersen, Johannes Schumacher, Stephen S Rich, Cisca Wijmenga, Shamil R Sunyaev, Paul IW de Bakker, Soumya Raychaudhuri

29. “Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.” Nature Genetics. 47(8):898-905. 2015

Xinli Hu, Aaron J Deutsch, Tobias L Lenz, Suna Onengut-Gumuscu, Buhm Han, Wei-Min Chen, Joanna MM Howson, John A Todd, Paul IW de Bakker, Stephen S Rich, Soumya Raychaudhuri

30. “Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci.” The American Journal of Human Genetics. 97(1):139-152. 2015

Gosia Trynka, Harm-Jan Westra, Kamil Slowikowski, Xinli Hu, Han Xu, Barbara E Stranger, Buhm Han, Soumya Raychaudhuri

31. “Accurate and Fast Multiple-Testing Correction in eQTL Studies.” The American Journal of Human Genetics. 96(6):857-868. 2015

Jae Hoon Sul, Towfique Raj, Simone de Jong, Paul IW de Bakker, Soumya Raychaudhuri, Roel A Ophoff, Barbara E Stranger, Eleazar Eskin¶, Buhm Han¶

32. “Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.” JAMA. 313(16):1645-1656. 2015

Sebastien Viatte, Darren Plant, Buhm Han, Bo Fu, Annie Yarwood, Wendy Thomson, Deborah PM Symmons, Jane Worthington, Adam Young, Kimme L Hyrich, Ann W Morgan, Anthony G Wilson, John D Isaacs, Soumya Raychaudhuri, Anne Barton

33. “A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk.” Annals of The Rheumatic Diseases. 74(1):170-176, 2015 January

Annie Yarwood, Buhm Han, Soumya Raychaudhuri, John Bowes, Mark Lunt, Dimitrios A Pappas, Joel Kremer, Jeffrey D Greenberg, Robert Plenge, Rheumatoid Arthritis Consortium International (RACI), Jane Worthington, Anne Barton, Steve Eyre

2014

34. “The HLA-DRβ1 Amino Acid Positions 11-13-26 Explain the Majority of SLE-MHC Associations.” Nature Communications. 5:5902, 2014 December

Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, Yukinori Okada, Buhm Han, Woei-Yuh Saw, Yik-Ying Teo, Sang-Cheol Bae

35. “Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations.” Human Molecular Genetics. 23(25):6916-26, 2014 December

Yukinori Okada, Kwangwoo Kim, Buhm Han, Nisha E Pillai, Rick T-H Ong, Woei-Yuh Saw, Ma Luo, Lei Jiang, Jian Yin, So-Young Bang, Hye-Soon Lee, Matthew A Brown, Sang-Cheol Bae, Huji Xu, Yik-Ying Teo, Paul IW De Bakker, Soumya Raychaudhuri

36. “Variation at HLA-DRB1 is associated with resistance to enteric fever.” Nature Genetics. 46(12):1333-6, 2014 December

Sarah J. Dunstan, Nguyen Thi Hue, Buhm Han, Zheng Li, Trinh Thi Bich Tram, Kar Seng Sim, Christopher M. Parry, Nguyen Tran Chinh, Ha Vinh, Nga Tran Vu Thieu, Phat Voong Vinh, Samir Koirala, Sabina Dongol, Amit Arjyal, Abhilasha Karkey, Olita Shilpakar, Christiane Dolecek, Jia Nee Foo, Le Thi Phuong, Mai Ngoc Lanh, Tan Do, Tin Aung, Do Nu Hon, Yik Ying Teo, Martin L Hibberd, Katherine L.  Anders, Yukinori Okada, Soumya Raychaudhuri, Cameron P. Simmons, Stephen Baker, Paul I.W. de Bakker, Buddha Basnyat, Tran Tinh Hien, Jeremy J. Farrar, Chiea Chuen Khor

37. “Fine-mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.” The American Journal of Human Genetics. 95(2):162-172. 2014 August

Yukinori Okada*, Buhm Han*, Lam C. Tsoi, Philip E. Stuart, Eva Ellinghaus, Trilokraj Tejasvi, Vinod Chandran, Fawnda Pellett, Remy Pollock, Anne M. Bowcock, Gerald G. Krueger, Michael Weichenthal, John J. Voorhees, Proton Rahman, Peter K. Gregersen, Andre Franke, Rajan P. Nair, Goncalo R. Abecasis, Dafna D. Gladman, James T. Elder, Paul I.W. de Bakker, and Soumya Raychaudhuri

38. “Effectively identifying regulatory hotspots while capturing expression heterogeneity in gene expression studies.” Genome Biology. 15(4):R61. 2014

Jong Wha J Joo, Jae Hoon Sul, Buhm Han, Chun Ye, Eleazar Eskin

39. “Fine-mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.” The American Journal of Human Genetics. 94(4):522-523. 2014

Buhm Han, Dorothee Diogo, Steve Eyre, Henrik Kallberg, Alexandra Zhernakova, John Bowes, Leonid Padyukov, Yukinori Okada, Miguel A. Gonzalez-Gay, Solbritt Rantapaa-Dahlqvist, Javier Martin, Tom W J Huzinga, Robert Plenge, Jane Worthington, Peter K. Gregersen, Lars Klareskog, Paul I. W. de Bakker, Soumya Raychaudhuri

40. “Fast Pairwise IBD Association Testing in Genome-wide Association Studies.” Bioinformatics. 30(2):206-13. 2014

Buhm Han*, Eun Yong Kang*, Soumya Raychaudhuri, Paul I. W. de Bakker, Eleazar Eskin

41. “Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice.” PLOS Genetics. 10(1): e1004022. 2014

Eun Yong Kang*, Buhm Han*, Nicholas Furlotte*, Jong Wha Joo, Diana Shih, Richard Davis, Aldons J. Lusis, Eleazar Eskin

2013

42. “Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells.” Proceedings of the National Academy of Sciences. 110(47):19030-5. 2013

Xinli Hu, Hyun Kim, Patrick J. Brennan, Buhm Han, Clare Baecher-Allan, Philip De Jager, Michael B. Brenner, Soumya Raychaudhuri

43. “Genome-wide association study of Tourette’s Syndrome.” Molecular Psychiatry. 18(6):721-8. 2013 June

Jeremiah M. Scharf, Dongmei Yu, Carol A. Mathews, Benjamin M. Neale, S. Evelyn Stewart, Jesen A Fagerness, Patrick Evans, Eric Gamazon, Christopher K. Edlund, Susan Service, Anna Tikhomirov, Lisa Osiecki, Cornelia Illmann, Anna Pluzhnikov, Anuar Konkashbaev, Lea K Davis, Buhm Han, Jacquelyn Crane, Priya Moorjani, Andrew T. Crenshaw, Melissa A. Parkin, Victor I. Reus, Thomas L. Lowe, Martha Rangel-Lugo, Sylvain Chouinard, Yves Dion, Simon Girard, Danielle C Cath, Jan H Smit, Robert A. King, Thomas Fernandez, James F. Leckman, Kenneth K. Kidd, Judith R. Kidd, Andrew J. Pakstis, Matthew State, Luis Diego Herrera, Roxana Romero, Eduardo Fournier, Paul Sandor, Cathy L Barr, Nam Phan, Varda Gross-Tsur, Fortu Benarroch, Yehuda Pollak, Cathy L. Budman, Ruth D. Bruun, Gerald Erenberg, Allan L Naarden, Paul C Lee, Nicholas Weiss, Barbara Kremeyer, Gabriel Bedoya Berro, Desmond Campbell, Julio C. Cardona Silgado, William Cornejo Ochoa, Sandra C. Mesa Restrepo, Heike Muller, Ana V. Valencia Duarte, Gholson J Lyon, Mark Leppert, Jubel Morgan, Robert Weiss, Marco A. Grados, Kelley Anderson, Sarah Davarya, Harvey Singer, John WalkupJoseph Jankovic, Jay A. Tischfield, Gary A. Heiman, Donald L. Gilbert, Pieter J. Hoekstra, Mary M. Robertson, Roger Kurlan, Chunyu Liu, J. Raphael Gibbs and Andrew Singleton for the North American Brain Expression Consortium, John Hardy for the UK Human Brain Expression Database, Eric Strengman, Roel Ophoff, Michael Wagner, Rainald Moessner, Daniel B. Mirel, Danielle Posthuma, Chiara SabattiEleazar Eskin, David V. Conti, James A. Knowles, Andres Ruiz-Linares, Guy A. Rouleau, Shaun Purcell, Peter Heutink, Ben A. Oostra, William McMahon, Nelson Freimer, Nancy J. Cox, David L. Pauls

44. “IPED: Inheritance Path Based Pedigree Reconstruction Algorithm Using Genotype Data.” Journal of Computational Biology. 20(10):780-91. 2013

Dan He, Zhanyong Wang, Buhm Han, Laxmi Parida, Eleazar Eskin

45. “Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches.” PLOS Genetics. 9(6): e1003491. 2013

Jae Hoon Sul*, Buhm Han*, Chun Ye*, Ted Choi, Eleazar Eskin

46. “Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens.” PLOS One. 8(6):e64683. 2013

Xiaoming Jia*, Buhm Han*, Suna Onengut-Gumuscu, Wei-Min Chen, Patrick J. Concannon, Stephen S. Rich, Soumya Raychaudhuri, Paul I.W. de Bakker

47. “Rare Variant Association Testing under Low- Coverage Sequencing.” Genetics. 194(3):769-79. 2013

Oron Navon, Jae Hoon Sul, Buhm Han, Lucia Conde, Paige Bracci, Jacques Riby, Christine Skibola, Eleazar Eskin, Eran Halperin

48. “Hap-seq: An Optimal Algorithm for Haplotype Phasing with Imputation using Sequencing Data.” Journal of Computational Biology. 20(2):80-92. 2013

Dan He, Buhm Han, Eleazar Eskin

49. “Chromatin marks identify critical cell types for fine mapping complex trait variants.” Nature Genetics. 45(2):124-30. 2013

Gosia Trynka, Cynthia Sandor, Buhm Han, Han Xu, Barbara E Stranger, X Shirley Liu, Soumya Raychaudhuri

~2012

50. “Incorporating prior information into association studies” Bioinformatics. 28 (12):i147-i153, 2012. Also appeared in Proceedings of the Twentieth Annual Conference on Intelligent Systems for Molecular Biology (ISMB-2012)

Gregory Darnell, Dat Duong, Buhm Han, Eleazar Eskin

51. “Interpreting Meta-Analyses of Genome-Wide Association Studies.” PLOS Genetics. 8(3):e1002555, 2012

Buhm Han, Eleazar Eskin

52. “Increasing Power of Groupwise Association Test with Likelihood Ratio Test.” Journal of Computational Biology. 18(11):1611-1624, 2011

Jae Hoon Sul, Buhm Han, Eleazar Eskin

53. “Random Effects Model Aimed At Discovering Associations in Meta-Analysis of Genome-Wide Association Studies.” The American Journal of Human Genetics. 88(5):586-598, 2011

Buhm Han, Eleazar Eskin

54. “An Optimal Weighted Aggregated Association Test for Identification of Rare Variants Involved in Common Diseases.” Genetics. 188(1):181-8, 2011

Jae Hoon Sul, Buhm Han, Dan He, Eleazar Eskin

55. “Postassociation Cleaning Using Linkage Disequilibrium Information.” Genetic Epidemiology. 35(1):1-10, 2011

Buhm Han, Brian Hackel, Eleazar Eskin

56. “Fine Mapping in 94 Inbred Mouse Strains Using a High-Density Haplotype Resource.” Genetics. 185(3):1081-1095, 2010

Andrew Kirby, Hyun Min Kang, Claire M. Wade, Chris Cotsapas, Emrah Kostem, Buhm Han, Nick Furlotte, Eun Yong Kang, Manuel Rivas, Molly A. Bogue, Kelly A. Frazer, Frank M. Johnson, Erica J. Beilharz, David R. Cox, Eleazar Eskin, Mark J. Daly

57. “Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers.” PLOS Genetics. 5(4):e1000456, 2009

Buhm Han, Hyun Min Kang, Eleazar Eskin

58. “Structural Alignment of Pseudo-knotted RNA.” Journal of Computational Biology. 15(5):489-504, 2008

Buhm Han*, Banu Dost*, Vineet Bafna, Shaojie Zhang

59. “Efficient Association Study Design via Power-Optimized Tag SNP Selection.” Annals of Human Genetics. 72(6):834-47, 2008

Buhm Han, Hyun Min Kang, Myeong Seong Seo, Noah Zaitlen, Eleazar Eskin


Refereed Domestic Journal Papers (KCI : Korea Citation Index)

60. “MergeReference: A Tool for Merging Reference Panels for HLA Imputation.” Genomics & informatics. 15(3):108-111. 2017Buhm Han, Hyun Min Kang, Myeong Seong Seo, Noah Zaitlen, Eleazar Eskin

Seungho Cook, Buhm Han

61. “Comparison of Two Meta-Analysis Methods: Inverse-Variance-Weighted Average and Weighted Sum of Z-Scores.” Genomics & informatics. 14(4):173-180. 2016

Cue Hyunkyu Lee, Seungho Cook, Ji Sung Lee, Buhm Han

62. “Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans.” Genomics & Informatics. 13(4):126-131. 2015

Soo Heon Kwak, Yoon Ji Kim, Jeesoo Chae, Cue Hyunkyu Lee, Buhm Han, Jong-Il Kim, Hye Seung Jung, Young Min Cho, and Kyong Soo Park


Refereed Conference Proceedings

63. “IPED: Inheritance Path Based Pedigree Reconstruction Algorithm Using Genotype Data.” In Proceedings of the Seventeenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2013). Beijing, China: April 7-10, 2013

Dan He, Zhanyong Wang, Buhm Han, Laxmi Parida, Eleazar Eskin

64. “Hap-seq: An Optimal Algorithm for Haplotype Phasing with Imputation using Sequencing Data.” In Proceedings of the Sixteenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2012). Barcelona, Spain: April 21-24, 2012

Dan He, Buhm Han, Eleazar Eskin

65. “Increasing Power of Groupwise Association Test with Likelihood Ratio Test.” In Proceedings of the Fifteenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2011). Vancouver, Canada: March 28-31, 2011

Jae Hoon Sul, Buhm Han, Eleazar Eskin

66. “An Adaptive and Memory Efficient Algorithm for Genotype Imputation.” In Proceedings of the Thirteenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2009). Tucson, AZ: May 18-21, 2009

Hyun Min Kang, Noah Zaitlen, Buhm Han, Eleazar Eskin

67. “Efficient Genome Wide Tagging by Reduction to SAT.” In Proceedings of the 8th Workshop on Algorithms in Bioinformatics (WABI-2008). Universitt Karlsruhe, Germany: September 15-17, 2008

Arthur Choi, Noah Zaitlen, Buhm Han, Knot Pipatsrisawat, Adnan Darwiche, Eleazar Eskin

68. “Structural Alignment of Pseudo-knotted RNA.” In Proceedings of the Tenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2006). Venice, Italy, April 2-5, 2006


Invited Review Papers

69. “Multiple Testing in Genetic Epidemiology.” Encyclopedia of Life Sciences. DOI:10.1002/9780470015902.a0022497, 2010

Buhm Han, Eleazar Eskin


Refereed Workshop Papers

70. “Leveraging Joint Test Status Distribution for an Optimal Signicance Testing.” In Proceedings of the NIPS 2009 Workshop on Machine Learning in Computational Biology. Whistler, CA: December 11th, 2009

Buhm Han, Chun Ye, Ted Choi, Eleazar Eskin