PLEIO (Pleiotropic Locus Exploration and Interpretation using Optimal test) : a summary-statistic-based framework to map and interpret pleiotropic loci in a joint analysis of multiple diseases and complex traits. Our method maximizes power by systematically accounting for genetic correlations and heritabilities of the traits in the association test. Any set of related phenotypes, binary or quantitative traits with different units, can be combined seamlessly. In addition, our framework offers interpretation and visualization tools to help downstream analyses. Using our method, we combined 18 traits related to cardiovascular disease and identified 13 pleiotropic loci, which showed four different patterns of associations.
Citation : Lee, C. H., Shi, H., Pasaniuc, B., Eskin, E., & Han, B. (2021). PLEIO: a method to map and interpret pleiotropic loci with GWAS summary statistics. The American Journal of Human Genetics, 108(1), 36–48. Link