CookHLA : an accurate and efficient HLA imputation method.
Human leukocyte antigen (HLA) genes in the major histocompatibility complex (MHC) region influence many immune-related disease phenotypes. Discovering which HLA alleles or amino acids drive phenotypes often requires fine-mapping analysis in tens of thousands of samples, of which HLA typing can be prohibitively costly. Fortunately, the recent development of imputation methods enabled the prediction of HLA alleles using intergenic SNP data, allowing many studies to fine-map HLA for immune phenotypes. Nonetheless, existing imputation methods still have limitations in accuracy.
Citation : Cook, S., Choi, W., Lim, H. et al. Accurate imputation of human leukocyte antigens with CookHLA. Nat Commun12, 1264 (2021). https://doi.org/10.1038/s41467-021-21541-5